Although genetic deletion of STING leads to impaired control of the intracellular bacteria L. monocytogenes, Chlamydia trachomatis, and Salmonella enterica (93, 137, 139), in the cecal ligation and puncture model of sepsis, loss of STING is protective against death and bacteremia (140, 141, 142). This evidence concerns the gene STING1 and bacterial infectious disease with sepsis.