AKT1 and exocrine pancreatic carcinoma: Pancreas-specific KrasG12D mice sufficiently developed pancreatic intraepithelial neoplasia using a Pdx1 promoter, and active Akt1 cooperated with KrasG12D to accelerate pancreatic carcinoma onset and progression (Albury et al. 2015; Ueda et al. 2019).