It was of interest to note that the activation of T antigen in PGC-positive cells caused breast triple-negative lobular carcinoma in female transgenic mice, in line with PGC-cre/PTENf/f (E et al. 2023) and K19-cre/PTENf/f mice (Czéh et al. 2010), but gastric and colorectal cancer in male mice. This evidence concerns the gene TBXT and colorectal cancer.