SMPD1 and neoplasm: The immunohistochemistry analysis of acid sphingomyelinase expression was graded from 0 (no detectable acid sphingomyelinase expression) to 3 + (strong expression of the acid sphingomyelinase) as shown in Fig. 1A. Correlation of the acid sphingomyelinase expression with patient survival data indicates that high expression of acid sphingomyelinase in the tumor tissue strongly correlated with improved prognosis of the patients with overall survival (Fig. 1B).