UCHL1 and colorectal carcinoma: Therefore, to determine the potential mechanisms of CHGA‐ and UCHL1‐mediated metastasis promotion in CRC, we transfected shRNA of CHGA and UCHL1 or scrambled shRNA lentiviral particles into HCT‐116 cells and observed downregulated protein level of UCH‐L1 and CHGA by CHGA and UCHL1 short hairpin RNAs (shRNA) (Figure 5A) in selected HCT‐116 cells.