Our data also shows that the CHGA and UCHL1 play a circuital role in mediating CRC development via Rho‐GTPase/AKT/NFκB signalling pathways‐mediated transcriptional activation of H3K4 of their promoters in the HCT‐116 cells (Figure 9). The gene discussed is UCHL1; the disease is colorectal carcinoma.