Furthermore, the protein level of PCNA (a marker for cell proliferation), MMP9 (a key regulator for EMT‐related metastatic capability), β‐catenin (a marker in advanced colorectal carcinoma) and N‐Cadherin (a marker for EMT transition in tumorigenesis) were significantly decreased in the shCHGA and shUCHL1 group tumours than those in the HCT‐116 shControl group tumours (Figure 8B). This evidence concerns the gene MMP9 and neoplasm.