Moreover, 11β-HSD1 regulates inflammatory responses, and we consistently observed that the knockdown of 11β-HSD1 lowered the expression levels of pro-inflammatory mediators (IL-6 and IL-1β) in the myocardium, suggesting a reduction in the levels of local inflammatory factors in the myocardium during endotoxemia. Here, IL1B is linked to serum lipopolysaccharide activity.