Activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is a regulatory factor for invasion and migration of liver cancer,[24] hematological malignancies,[25] breast cancer, and head and neck cancer.[26] The suppressor of cytokine signaling (SOCS) protein family is believed to negatively regulate JAK/STAT signaling in multiple diseases.[27] Nevertheless, the function of the SOCS protein family in regulating the JAK‐STAT pathway in smoking‐induced NSCLC progression is unclear. Here, CISH is linked to head and neck cancer.