Abnormal regulation of the JAK‐STAT pathway participates in the pathogenesis of various malignant tumors.[50, 51, 52] Further, as a negative regulator, SOCS2 is involved in activation of the JAK‐STAT signaling pathway.[53, 54] For A549 and H1703 cells, down‐regulated circEML4 in EVs changed the over‐expression of p‐JAK2 and p‐STAT5 and the down‐expression of SOCS2 caused by EVs from CSE‐induced M2 macrophages; however, low expression of ALKBH5 alleviated the effect of the circEML4 siRNA. This evidence concerns the gene JAK2 and cancer.