Within EVs, circRNAs have been found to be highly stable and conserved.[55] circRNAs in EVs not only retain their functions but also participate in complex intercellular communications within the TME.[56, 57] Therefore, EVs are considered as biomarkers for diagnosis of various diseases, including tumors.[58, 59] Engineered EVs can be used as drug therapy vectors, and lncRNA MEG3 in EVs can be used as potential therapeutic target for osteosarcoma.[60] Our results suggest that circEML4 in EVs is a target for regulating malignant progression of NSCLC. The gene discussed is MEG3; the disease is non-small cell lung carcinoma.