IGF2BP1 and neoplasm: As part of RNA processing, m6A modification participates in export, translation, splicing, and degradation.[46, 47] In bladder cancer cells, circPTPRA binds to IGF2BP1 to regulate m6A modification and affects the degree of tumor malignancy.[48] Our results showed that circEML4 binds to ALKBH5, increasing the distribution of ALKBH5 in the cytoplasm and decreasing its distribution in the nucleus, thereby increasing the m6A modification levels in NSCLC cells.