JAK2 and cancer: SOCS2 regulates JAK‐STAT signaling in cancer cells.[30, 31] Our data indicated that low expression of circEML4 attenuated the upregulation of p‐JAK2 and p‐STAT5 and the downregulation of SOCS2 induced by EVs from CSE‐THP‐M (Figure S18A,B, Supporting Information).