Similar, compared to participants with APOE e4 non-carries and low vitamin D status, the HRs (95% CIs) of dementia were 4.21 (3.62–4.90) and 2.54 (2.22–2.92) for those with APOE e4 carries plus low vitamin D status, and 3.23 (2.75–3.79) and 2.08 (1.82–2.39) for those with APOE e4 carries and high vitamin D status among women and men, respectively. This evidence concerns the gene APOE and dementia.