APOE and dementia: After fully-adjusted for confounding factors, compared to participants with APOE e4 non-carries and low handgrip strength, the HRs (95% CIs) of dementia were 3.65 (3.22–4.15) and 2.84 (2.54–3.19) for those with APOE e4 carries plus low handgrip strength among women and men, respectively, and 2.45 (2.01–2.99) and 1.67 (1.39–2.01) for those with APOE e4 carries and high handgrip strength among women and men, respectively.