APOE and dementia: In joint effect analysis, compared to participants with both low handgrip strength/low vitamin D and APOE e4 non-carries, the HRs (95% CIs) of dementia were 4.29 (3.52–5.22) and 2.62 (2.2.20–3.14) in those with APOE e4 carries plus low handgrip strength/low vitamin D profiles among women and men, respectively, and 2.41 (1.77–2.33) and 1.26 (0.94–1.68) in those with APOE e4 carries and both high handgrip strength and vitamin D profiles among women and men, respectively.