In women and men, respectively, participants who developed dementia were more likely to be older, excessive alcohol consumption, former or current smokers, obesity, APOE e4 carriers, had low education attainment and socioeconomic status, had high prevalence of heart disease, stroke, hypertension, diabetes, and depression, and less likely to have higher level of vitamin D and handgrip strength comparted to those who did not develop dementia. The gene discussed is APOE; the disease is major depressive disorder.