G0S2 and glioblastoma: Next, to identify crucial genes that influence the IDH status and prognosis of GBM, the 105 genes highly expressed in subgroup B, GBM-related genes obtained from GeneCards and OMIM database and three high-risk genes for constructing a prognostic risk model (MMP19, G0S2 and RARRES2) were used for intersection analysis; ultimately, RARRES2 was screened (Fig. 6D).