The ERBB signaling pathway is a large and complex system that regulates the downstream RAS/MAPK, AKT, JAK/STAT, and Src/FAK signaling axes involved in tumor cell migration, and TPM3 is a component of the “pathways in cancer” network (KEGG: map05200).37 In particular, the Src/FAK signaling axis plays an important role in local adhesion and stiffness sensing processes.38 The potential feedback loop between mutant TP53 and the ERBB signaling pathway warrants further exploration. This evidence concerns the gene PTK2 and cancer.