EGFR and neoplasm: The ERBB signaling pathway is a large and complex system that regulates the downstream RAS/MAPK, AKT, JAK/STAT, and Src/FAK signaling axes involved in tumor cell migration, and TPM3 is a component of the “pathways in cancer” network (KEGG: map05200).37 In particular, the Src/FAK signaling axis plays an important role in local adhesion and stiffness sensing processes.38 The potential feedback loop between mutant TP53 and the ERBB signaling pathway warrants further exploration.