In this study, we identified several new candidate genes for epilepsy, such as WIPF1, IQSEC1, JAM2, ICAM3, and ZNF143. WIPF1 (WAS/WASL interacting protein family member 1, related to endocytosis) has been identified by TWAS and mRNA expression profiles. The gene discussed is IQSEC1; the disease is epilepsy.