While full-body knockout of Raptor in mice is embryonically lethal [14], targeting Raptor in mature adipocytes via the adiponectin-Cre system demonstrated that raptorAdipoq-cre mice were resistant to high fat-diet-induced obesity and adipose tissue expansion leading to lipodystrophy [28]. The gene discussed is RPTOR; the disease is obesity due to melanocortin 4 receptor deficiency.