Brain cancer and glioma are the result of another miRNA-lncRNA interaction: GAS5, which interacts with miR-10b and promotes metastasis by activating mitogen-activated protein kinase kinases (MEK), protein kinase B (AKT), phosphoinositide 3-kinase (PI3K), and extracellular signal-regulated kinase (ERK), and PTEN pathway. Here, AKT1 is linked to central nervous system cancer.