HOTAIR and colorectal carcinoma: The lncRNA HOTAIR interacts with miR-218, miR-545, and miR-203a-3p via a negative impacting mechanism, producing up-regulation of EGFR, β-catenin, Groucho related gene 5 (GRG5), and VOPP1 pathways, resulting in chemotherapy resistance and invasion in CRC [114, 115].