To increase pancreatic cancer cell motility, invasion, EMT, and lung metastasis by secreting IL-10, TGF-β, and arginase-1, EV-miR-301a interacts with HOTAIR and MIR31HG from hypoxic pancreatic cancer cells and causes macrophage M2 polarization [101]. Here, TGFB1 is linked to familial pancreatic carcinoma.