These 21 genes with hypermethylation or gain included oncogenes UCHL1, MLLT11, SLC35F2, SEMA6D, and ARHGEF39 and tumor suppressors SOD2, RASSF2, and TRIM13. The hypomethylation or loss category included three genes, none of which are known drivers in cancer. Here, SEMA6D is linked to cancer.