After using NASH induced by MCD diet, it was found that KCs [22],NKT cells [21], DC cells [25] and NK cells [26] were significantly activated, and CD4T lymphocytes were significantly recruited [27], cytokines such as IFN-γ, IL1α, IL1β, IL12 (p40), GM-CSF, and CCL3 secreted by these cells are also higher. This evidence concerns the gene IL1A and metabolic dysfunction-associated steatohepatitis.