For example, in gallbladder cancer41, LncRNA-PAGBC binds to the tumor-suppressor microRNAs miR-133b and miR-511 in a competitive manner, titrating the miRNAs from the SOX4 and PIK3R3 binding sites and activating the AKT/mTOR signaling cascade. This evidence concerns the gene PIK3R3 and neoplasm.