TGFB1 and neoplasm: In addition to the anti-carcinogenicity that eribulin achieves by inhibiting microtubule dynamics, the agent plays a role in mechanisms such as tumor microenvironment alteration7, the reversion of epithelial mesenchymal transition (EMT)8,9, the inhibition of TGF-β signaling10, vascular remodeling11, the elimination of tumor hypoxia12, the inhibition of tumor migration invasion and metastasis13, and the inhibition of telomerase reverse transcriptase RNA-dependent RNA polymerase (TERT-RdRP)14.