In this study, we uncovered the oncogenic function of NCBP1 in DLBCL, proved that NCBP1 increases METTL3 mRNA transcript stabilization, and verified that NBCP1 impacts METTL3-mediated m6A modification of c-MYC in the forthcoming tumorigenesis of DLBCL. This evidence concerns the gene METTL3 and diffuse large B-cell lymphoma.