Then, we downregulated c-MYC expression in SU-DHL4 cells and DB cells (Fig. 5D,E and Supplementary Fig. S2C,D) and found that METTL3-enhanced proliferation of DLBCL cells could be blocked by silencing c-MYC by CCK-8 (Fig. 5F,G and Supplementary Fig. S2E,F) and EdU incorporation assays (Fig. 5H,I). This evidence concerns the gene MYC and diffuse large B-cell lymphoma.