METTL3 and osteoarthritis: For example, METTL3 regulates autophagy by enhancing m6A modification of ATG7 in osteoarthritis progression28; METTL3 mediates BCL2 stability via Ythdf1-mediated m6A modification and inhibits cell apoptosis29; METTL3 regulates lncRNA stability and improves CUL4B enter into the nucleus30.