Our study proves that METTL3 promotes the proliferation of DLBCL cells by regulating the m6A methylation of c-MYC, which further clarified the mechanisms of m6A methylation system abnormalities in DLBCL and revealed that substrates for METTL3 in DLBCL have obvious diversity. The gene discussed is METTL3; the disease is diffuse large B-cell lymphoma.