MYD88 and cancer: To better understand the effects of RT in Lyz2-Cre/Myd88fl/fl mice on the tumor environment following treatment, we performed NanoString analysis using the Pan-Cancer Immune Profiling panel of whole tumors 7d post-RT, which revealed increased gene expression signatures indicative of leukopoiesis/lymphopoiesis, lymphocyte chemotaxis, and T cell development when myeloid cells lack MyD88 (Fig. 6B,C and Supplemental Fig. S7A).