Differential gene expression analysis of significantly regulated genes in Myd88-deficient Itgam+Csf1r+Adgre1+ (CD11b+CSF1R+F4/80+) cells (all macrophages/monocytes) revealed increased gene expression of interferon-responsive genes (e.g. Ifit1/2, Irf7, Stat1/2, and Cxcl10), and decreased expression of some genes associated with Th2/M2-type macrophages (e.g. Mmp9, Lmna, Stat1) and recruitment of tumor-associated neutrophils (Cxcl2)39 (Fig. 4A,B). This evidence concerns the gene MMP9 and neoplasm.