MACROH2A2 and glioblastoma: Interestingly, RNA-seq datasets of GBM from regionally sampled mouse xenografts67 and human tumors68 show increased MACROH2A2 expression in the tumor core, with lower levels at the margin or infiltrating edge (p = 0.024 for GSE139261 and p = 0.0094 GSE117891; Wilcoxon test) (Fig. S4d, e).