Actually, recent research suggests that TEs could change the local functional architecture of HARs in schizophrenia and bipolar disorder [29] and our present findings add a further layer of support to this hypothesis, showing that 12 of the 38 significant nrTEs fall within the ORF of genes that are enriched for a neurodevelopmental process, the “regulation of neuron projection development” (ADAMTS1, ANKRD55, CRIM1, EDIL3, LRRC4C, LRRC7, MAF, NAV2, QDPR, TENM3, TSPAN11, XKR4). This evidence concerns the gene XKR4 and bipolar disorder.