Specifically, the double knockout of LDLR and AMPKα2 in mice promotes ER stress and accelerates the development of atherosclerosis.430 AMPK inhibits endothelial inflammation by phosphorylating the transcriptional coactivator p300 in human umbilical vein endothelial cells (HUVECs).431 Sterol SREBP-1c is phosphorylated by AMPK at Ser372, which reduces lipogenic transcription in hepatic cells.375. The gene discussed is LDLR; the disease is atherosclerosis.