α2,3-Sialyltransferase IV (ST3Gal-IV) deficiency in mice protects against atherosclerosis, as the glycosylation of C-C motif chemokine receptor 5 (CCR5) is impaired, leading to decreased leukocyte rolling.74 Loss of α(1,3) fucosyltransferases-IV (FucT-IV) and FucT-VII reduces the glycosylation of selectin ligands and leukocyte recruitment, decreasing atherosclerotic lesions.459,460 Core 2 β1,6 galactosyltransferase I deletion prevents atherosclerosis by reducing glycoproteins in selection ligands such as CD43, CD44, and CD162 and inhibiting their activity.461. This evidence concerns the gene SPN and atherosclerosis.