In a study, adenovirus-mediated overexpression of hepatic NH(2)-terminal myristoylated signal-attached Akt (myr-Akt) leads to hypertriglyceridemia, hypoglycemia and hypoinsulinemia, which is regulated by Akt-mediated SREBP1 expression and fatty acid biosynthesis in an SREBP1-independent manner.88 The gene discussed is SREBF1; the disease is hypertriglyceridemia.