SIRT1 can accelerate the deacetylation of PPARγ to induce the browning of WAT.279 SIRT2 deacetylates the p65 subunit of NF-κB and RIP-1.280 SIRT3 and SIRT4 are located in mitochondria and regulate energy expenditure.281 SIRT5 and related acylation can reduce liver steatosis in ob/ob mice.282 SIRT6 is a FOXO1 deacetylase that drives lipid catabolism.283. The gene discussed is SIRT6; the disease is fatty liver disease.