INS and type 2 diabetes mellitus: Reduced Glut-2 murine N-glycosylation and GlcNAcT-IV expression are associated with diabetes induced by a high-fat diet.247 GlycA is identified as a marker of systemic inflammation that originates from N-acetylglucosamine, and systemic inflammation may likely contribute to T2DM occurrence by causing insulin resistance and β cell dysfunction.248 Supplementation with sialic acid or the sialic acid precursor N-acetyl-D-mannosamine may restore anti-inflammatory properties and preserve insulin sensitivity.249