Hepatic USP4 is directly bound to deubiquitinated TAK1, leading to amelioration of metabolic dysfunction.341 The USP7/ZNF638 axis mediates de novo lipogenesis.342 Ubiquitin-specific peptidase 10 (USP10) decreases over time in patients with NAFLD and in HFD-fed mice. This evidence concerns the gene USP10 and metabolic dysfunction-associated steatotic liver disease.