SRSF3 degradation via lysin11 neddylation partially protects mice from NAFLD and deletion of SRSF3 predisposes to hepatocellular carcinoma in mice.350 In addition, dysregulation of NRF2 by neddylation of cullin 3 was connected with AGER1 downregulation and NASH aggravation.351 It has been demonstrated that neddylation inhibition in vivo in NAFLD pre-clinical models inhibits mTOR activation and induced protein DEP-domain containing mTOR-interacting protein (DEPTOR), thus mediating anti-steatotic effects as well as boosting hepatic fatty acid oxidation.352. Here, CUL3 is linked to metabolic dysfunction-associated steatotic liver disease.