PRDM16 and obesity due to melanocortin 4 receptor deficiency: EHMT1 expression positively regulates brown adipose energy homeostasis by stabilizing the PRDM16 protein and depositing the suppressive H3K9me2 and H3K9me3.286 Specific deletion of adipose EHMT1 leads to obesity, systemic insulin resistance and adaptive thermogenesis.286 Lacking muscle-specific EHMT2 are resistant to high-fat diet (HFD)-induced obesity and hepatic steatosis in female mice.287 JMJD1A is another H3K9 demethylase that binds to the Ucp1 gene and decreases levels of H3K9me2 to regulate metabolic gene expression and obesity resistance.288