TRIM8 and TRIM16 can mitigate hepatic steatosis and fibrogenesis in NASH.338 The E3 ligase FBXW5 mediates ASK1 ubiquitination and exacerbates NASH.339 Liver and adipocytic MKRN1 is an E3 ubiquitin ligase for AMPK. Here, FBXW5 is linked to metabolic dysfunction-associated steatohepatitis.