OGT and obesity due to melanocortin 4 receptor deficiency: OGT targets adipose lipid desaturation to drive obesity, and the deletion of adipocyte OGT abolishes HFD-induced hyperphagia and obesity in mice.302 Loss of OGT can also decrease O-GlcNAcylation of lipid droplet-associated perilipin 1 (PLIN1), elevate PLIN1 phosphorylation and promote lipolysis in visceral fat to relieve diet-induced obesity.303