SRSF3 and Hepatic fibrosis: More recently, neddylation was described for the first time in liver fibrosis and is found to be deregulated in patients with liver fibrosis and CCl4-induced fibrosis mice.353 Preventing the neddylation-dependent degradation of serine-rich splicing factor 3 (SRSF3) protected mice from hepatic steatosis, fibrosis and inflammation.350 The neddylation modification of TGFβ-RII plays a critical role in HSC activation.353,354