CUL2 stabilized PRDM16 protein to repress adipocyte thermogenesis and counteracted diet-induced obesity by catalyzing its polyubiquitination.153 A study showed that fatty acid binding protein 4 (FABP4) was higher in the adipose tissues of obese diabetic patients. This evidence concerns the gene PRDM16 and obesity due to melanocortin 4 receptor deficiency.