NO suppresses platelet aggregation via S-nitrosylation.476 eNOS knock-out mice exhibit upregulated leukocyte rolling, increased exocytosis, and enhanced arteriolar thrombosis.477 Heat shock protein 90 (HSP90) S-nitrosylation inhibits the HSP90-ATPase activity 1 (AHA1) interaction but stimulates the HSP90-cell division cycle 37 (CDC37) association, which modulates endothelial dysfunction and exacerbates atherosclerosis.478 Guanine nucleotide-binding protein G(i) subunit alpha-2 (SNO-GNAI2) S-nitrosylation increases in individuals with diabetes and atherosclerosis. The gene discussed is GNAI2; the disease is endothelial dysfunction.