Recently, Song and colleagues found that inhibition of asialoglycoprotein receptor 1 (ASGR1) would upregulate ABCA1, ABCG5/ABCG8, LXRα, suppress SREBP and lipogenesis, subsequently facilitate cholesterol excretion and alleviate hyperlipidemia.45 Mechanistically, ASGR1 deficiency decreased LXRα ubiquitination, whereas overexpression of ASGR1 increased its ubiquitination.45 Here, NR1H3 is linked to hyperlipidemia.