SLC2A4 and type 2 diabetes mellitus: T1DM and T2DM show increased H3K9me3 of the Slc2a4 promoter and decrease glucose transporter type 4 (GLUT4) expression, thus contributing to glycemic impairment.224 KDM6A, one of the known H3K27me2/3 demethylases, has higher protein levels in the kidneys of diabetic OVE26 mice.224 Combination therapy with telmisartan and esculetin, attenuates increased levels of histone PTMs such as H3K9me2, H3K9Ac, H2AK119Ub, and H2BK120Ub in type 2 diabetic cardiomyopathy.225