When the treatment (1000 mg of curcumin plus 10 mg of piperine per day) was administered to patients with T2DM for 12 weeks, patients showed an inrecese in adiponectin and a decrease in the leptin: adiponectin ratio, leptin levels and TNF levels, independently of weight changes.525 A meta-analysis of nine trials with a combined total of 262 animals revealed that curcumin had a significant impact on blood vessel density and the pace of wound healing, suggesting that it could be a likely candidate for the treatment of diabetic foot ulcers.526. The gene discussed is TNF; the disease is type 2 diabetes mellitus.