The myoblast-like program, like that found in FN RMS tumours, was marked by the expression of terminal myogenic differentiation genes, such as MYOG, TTN and CKB. Finally, the program termed “satellite cell-like” (SC-like) was characterised by the expression of the NOTCH3 receptor gene, Notch pathway targets, including HEY1 and HES1, and genes encoding type V and VI collagens. The gene discussed is HES1; the disease is neoplasm.