Within T cell subgroups, the expression of several genes encoding molecules associated with immune dysfunction and the suppression of immune responses24 was observed, including LAG3 and PDCD1 (PD1) in CD8 + T cells, CTLA4 and TIGIT in Tregs and HAVCR2 in NK cells (Supplementary Fig. 3c). The gene discussed is HAVCR2; the disease is immune system disorder.