Although our data indicate upregulation in surface LAG-3 rather than PD-1 among neoepitope-specific T cells and the scrutinization of the splenic rather than the tumor compartment, the elevated levels of TIM-3 and LAG-3 among neoepitope-specific CD8+ T cells may reflect increased systemic immunosuppression with unfavorable implications for the capacity to control tumor growth. This evidence concerns the gene LAG3 and neoplasm.