In this model, both T-cell compartments have been scrutinized for their importance in other publications: some studies assign a key role to CD4+ T cells, as MHC class II-restricted neoepitope immunization results in B16F10 tumors elimination18, while a recent publication pointed to a single MHC class I-restricted epitope and CD8+ T cells able to facilitate B16F10 tumor control45. The gene discussed is CD4; the disease is neoplasm.