COL5A3 and myocardial infarction: The expression levels of representative fibrosis genes, including Tgfb1 and Tgfb2 for TGF-β signaling pathway and Col5a3 for collagen fibril organization were elevated in MI group compared to Sham group, and decreased in iCarP + /Light+ group, supporting the effects of iCarP triggered in situ photosynthesis on fibrosis in reducing fibrosis (Supplementary Fig. 10).