ATXN3 and neurodegenerative disease: Since it is well known that HspB8 is able to affect protein aggregation in neurodegenerative diseases (Carra, Seguin, Lambert, & Landry, 2008a; Chowdary et al., 2004; Kim et al., 2004; Sanbe et al., 2007), chaperone‐like activity of HspB8 was assessed on the Josephin domain (JD), structured region that triggers the aggregation process of ataxin‐3 (ATX3) and displayed amyloidogenic properties when incubated alone (Masino et al., 2011; Robertson et al., 2010).