In this complex scenario, at first we demonstrated the capability of HspB8 to inhibit the aggregation of the Josephin domain, the structured part of the ataxin‐3 protein (ATX3) that triggers the earliest steps of the expanded ATX3 fibrillation and the onset of the Spinocerebellar Ataxia type 3 (Masino et al., 2011; Robertson et al., 2010). This evidence concerns the gene ATXN3 and Spinocerebellar ataxia type 3.