Moreover, we employed the Josephin domain of the ataxin‐3, the poly‐Q containing protein responsible for the spinocerebellar ataxia Type 3 (Matos et al., 2011; Orr & Zoghbi, 2007), as an amyloid protein model to study the chaperone‐like activity of HspB8 alone and in the HspB8‐BAG3 complex. Here, HSPB8 is linked to Spinocerebellar ataxia type 3.