SQSTM1 and amyotrophic lateral sclerosis: While changes in p62 ubiquitylation by mutant cyclin F were modest in the cell lines, these abnormal changes are likely to underly late disease onset such as seen in ALS and FTD [57–59] leading to the significantly increased ubiquitylation of p62 observed at the end stage of disease in patient spinal cord motor neurons compared to controls.