While changes in p62 ubiquitylation by mutant cyclin F were modest in the cell lines, these abnormal changes are likely to underly late disease onset such as seen in ALS and FTD [57–59] leading to the significantly increased ubiquitylation of p62 observed at the end stage of disease in patient spinal cord motor neurons compared to controls. Here, CCNF is linked to amyotrophic lateral sclerosis.