Merlin, also known as the protein neurofibromin 2 (NF2), is a widely studied tumor suppressor that activates the Hippo pathway to inhibit YAP/TAZ activity via the mechanism of targeting LATS1/2 and improving the phosphorylation and activation of YAP/TAZ by MST1/2 [29]. This evidence concerns the gene MST1 and neoplasm.