In breast cancer patients, the low-level expression of circ_0000911 correlated with poor prognosis, and it was further noticed that overexpression of miR-449a sponges circ_000911 with Notch1, regulating NF-κB signalling, and induces the apoptosis and suppress the proliferation, invasion, and metastasis of breast cancer cells (Abdollahzadeh et al. 2019). This evidence concerns the gene NOTCH1 and breast cancer.