Whereas TMEM119 was present in some CD14+HLA-DRhi round-shaped cells (Fig. 3a, b, insets “c” and “d”), CD14+HLA-DR−/low-cells lacked TMEM119 immunoreactivity, not only in those cells within MS lesions (Fig. 3a, b, inset “c”), but also in blood vessel-associated cells (Fig. 3a, b, inset “d”), indicating their peripheral origin as monocyte-derived cells. Here, TMEM119 is linked to myeloid sarcoma.