The immunoregulatory role of MDSCs has been demonstrated in the experimental autoimmune encephalomyelitis (EAE) MS model [31, 48], where M-MDSCs (CD11b+Ly-6ChiLy-6G−/low, also called Ly-6Chi cells) have stronger immunosuppressive activity than PMN-MDSCs (CD11b+Ly-6CintLy-6Ghi) [6, 48]. This evidence concerns the gene ITGAM and experimental autoimmune encephalomyelitis.