TTN and familial dilated cardiomyopathy: Previous studies indicate that several genes may contribute to the initiation, progression and pathology of DCM, including titin (TTN), beta‐myosin heavy chain (MYH7), Cardiac troponin T(TNNT2), Desmoplakin (DSP), lamin A/C (LMNA), type V voltage‐gated cardiac Na channel gene (SCN5A), RNA‐binding motif protein 20 (RBM20) et al.6, 7, 8, 9, 10However, although these genes are apparently associated with DCM, limited are directly contributing to the development of DCM due to variations in genetics.