FOXP3 and immunodeficiency disease: They were also previously detected in most patients with APS-1 [92]; in some patients with combined immunodeficiency due to hypomorphic recombination activating genes (RAG)-1 or RAG-2, Omenn’s syndrome, leaky severe combined immunodeficiency, T-cell lymphopenia, and ataxia-telangiectasia [93]; in men with X-linked enteropathic polyendocrine immunodysregulation and forkhead box P3 (FOXP3) mutations [94]; and in women with incontinentia pigmenti and heterozygous “null” mutations in X-linked NEMO syndrome [5].