Herein, we show that RSV experimental infection of adult Nrf2-deficient BALB/c mice (Nrf2−/−; Nrf2 KO) is characterized by enhanced disease, increased inflammatory cell recruitment to the bronchoalveolar compartment and a more robust upregulation of innate and inflammatory genes and proteins, compared to wild-type Nrf2+/+ competent mice (WT). This evidence concerns the gene NFE2L2 and infection.