NFE2L2 and viral infectious disease: While some viral infections have been shown to activate Nrf2, among them hepatitis B and C viruses, human cytomegalovirus, Kaposi’s sarcoma-associated herpes virus and Marburg virus [13,14,15,16,17,18], respiratory viruses, including RSV, hMPV, influenza and SARS-CoV-2 are associated with a progressive reduction in Nrf2 cellular levels and subsequent inhibition of AOE expression [7,19,20].