As can be seen from the figure, the genes are enriched in pathways which include Vibrio cholerae infection (SEC61A1, ARF1, ACTB), Amyotrophic lateral sclerosis (POM121, NUP188, PSMD2, CYC1, ACTB), Pathogenic Escherichia coli infection (ARF1, NCL, ACTB), Coronavirus disease (RPS14, RPS25, RPLP2), Salmonella infection (ARF1, DYNLL1, ACTB), AMPK signaling pathway (PPP2R1A, PFKP) and Thyroid hormone signalling pathway (ACTB, PFKP). The gene discussed is ARF1; the disease is amyotrophic lateral sclerosis.