ITIH4 and infection: Figure 8A shows a range of C50 among the different CD4mcs. This measure correlates their capacity to sensitize HIV-1-infected cells to ADCC (Figure 8B) and infection inhibition (Figure 8C). These results are significant because BLI used the coree gp120 from a Clade A/E recombinant HIV-1, whereas the ADCC assays used cells infected with Clade B HIV-1AD8, and the neutralization assays used another Clade B HIV-1, CH58TF, thus suggesting that strongly conserved features of gp120 determine the vulnerabilities of HIV-1 Envs to CD4mcs.