Subsequently, the liver tissues of 4 HBV-HCC patients and 2 normal liver tissues were randomly selected for Western blot detection, and the results indicated that the expression of RSK2, p-RSK2, and CREB in HBV-HCC cancer tissues was significantly higher than in HBV-HCC-adjacent tissues, HBV-HCC-distal tissues, and normal liver tissues (Figure 5C). The gene discussed is CREB1; the disease is hepatocellular carcinoma.