CREB staining was performed on the same tissue microarrays, and CREB expression was significantly higher in HBV-HCC cancer tissues than in HBV-HCC-adjacent tissues, HBV-HCC-distal tissues, and normal liver tissues, with statistically significant differences (p < 0.001) (Figure 5B). The gene discussed is CREB1; the disease is hepatocellular carcinoma.