In order to determine whether this could be due to an inhibition of miRNA biogenesis during severe COVID-19, we compared mRNA expression of genes involved in miRNA biogenesis, namely AGO2, DICER1, DGCR8, DROSHA, and XPO5, in nasopharyngeal swabs of severe and non-severe COVID-19 patients and controls. This evidence concerns the gene AGO2 and COVID-19.