The potential of (p-BthTX-I)2K to inhibit enzymatic activities, as observed with SARS-CoV-2, may be related to its effect on the post-entry steps of ZIKV infection, with the potential target being the NS2B-NS3 complex (protease) or NS5 (RNA polymerase) of ZIKV [46]. Here, RAF1 is linked to Zika virus infectious disease.