In a study on the dynamics of adaptive immune response in severe COVID-19 examining the plasmablast transcriptome changes over the course of eight weeks, plasmablasts showed a continuous immune reaction; during the first week, plasmablasts showed an immune response directed against SARS-CoV-2, characterized by the synthesis of IgG antibodies against the spike and nucleocapsid proteins, but later response switched to IgA-expressing plasmablasts, which were are not specific to SARS-CoV-2 proteins and reflected continued instruction of the B lymphocytes by TGF-β1 [82]. This evidence concerns the gene TGFB1 and COVID-19.