This report confirms a higher IFN-γ response to SARS-CoV-2 antigen stimulation in vaccinated PAD patients than in unvaccinated patients who were exposed to the SARS-CoV-2 virus via natural COVID-19, similar to that previously reported in individuals in the general population [74,86], although conflicting evidence exists [87]. The gene discussed is IFNG; the disease is COVID-19.