During enterovirus infection, the viral components and replication intermediates activate retinoic acid-inducible gene I (RIG-1)-like receptor and MDA5, which will interact with the mitochondrial antiviral-signaling protein (MAVS, also known as IPS1) to activate immune response to inhibit viral replication and transmission [12,13,14]. This evidence concerns the gene MAVS and enterovirus infectious disease.