Notably, the down-regulated genes, that were specific to infection with the sfRNA-producing WT virus, included regulators of neuron differentiation, such as DLX6, DLX5, and FOXG1 (Figure 1A), which indicates that the production of sfRNA may contribute to the dysregulation of brain development in ZIKV infections. This evidence concerns the gene DLX5 and Zika virus infectious disease.