After observing that the increased catalytic activity of POP and PRCP is not typical in the young, but more pronounced in elderly individuals with comorbidities or previous cardiovascular events, Angeli and colleagues [103] have hypothesized that the adverse reactions to COVID-19 vaccination associated with Ang II accumulation (that they named “Spike effect” of COVID-19 vaccines), are reasonably expected to be more common in younger and healthy subjects. This evidence concerns the gene AGT and COVID-19.