TNF and Huntington disease: When analyzing cytokine-producing CD4+ T cells, we observed that after the primary scheme, the KT patients and the controls showed a higher proportion of triple positive CD4+ polyfunctional T cells (CD4+IFN-γ+IL-2+TNF-α+) than the HD patients (Figure 3F), consistent with a stronger T cell induction with mRNA vaccines in this group of immunocompromised patients [21,23].