In contrast, luminescent signals were undetectable in the lungs or brains of MVA-Sdg- or MVA-Spf-immunized animals throughout the course of infection, with the exception of one MVA-Sdg-immunized mouse that succumbed to infection at 8 d.p.i. Interestingly, we observed nLuc signal in the nares of control-immunized mice at 5–6 d.p.i., indicating the presence of transmissible virus which was absent in any of the MVA-Sdg- or MVA-Spf-immunized animals (Figure 6B–D). The gene discussed is SEC14L2; the disease is infection.