During infection, the Th1/Th2 responses and the immune-modulating activities by regulatory T (Treg) and B (Breg) cells reflect the interaction between the host immune system and the development of the parasite inside the host, with Th1 (pro-inflammatory) responses (production of IFN-γ, TNFɑ, IL-6, and IL-1) prevailing in the initial acute phase, followed by a Th2 response stimulated by egg antigens and characterized by the production of IL-4, IL-5, IL-13 and IL-10 [9,10,11]. The gene discussed is TNF; the disease is infection.