Schilling and colleagues found that mutant T151A inhibited HSV-1 and MCMV replication (an alpha- and betaherpesvirus, respectively) but not infection by murine gamma herpesvirus 68 (MHV68, a gammaherpesvirus), pointing to different hMX2 requirements for the inhibition of distinct herpesviruses [47]. The gene discussed is HMX2; the disease is infection.