The most relevant ICD-associated DAMPs considering the clinical response of tumor cells are (1) the secretion of adenosine triphosphate (ATP); (2) the extracellular release of High Mobility Group Box 1 (HMGB1); and (3) the exposure of endoplasmic reticulum chaperone Calreticulin (CRT) on cell membrane [16,17]. This evidence concerns the gene HMGB1 and neoplasm.