TNFSF10 and acute promyelocytic leukemia: Furthermore, antiproliferative activity has been reported in various cell lines, such as acute promyelocytic leukemia (APL), by inducing apoptosis through the mitochondrial pathway and causing cell cycle arrest in the G2/M phase [32], and in diffuse large B-cell lymphoma (DLBCL) cells, by enhancing apoptosis induced with TRAIL (tumor necrosis factor (TNF) related apoptosis-inducing ligand) [25].