Another mimetic peptide that has been based on a dimeric version of 4F, with a total of eight phenylalanine residues in the sequence of two 4Fs linked with a proline, has been studied in atherosclerosis and adipose tissue browning, demonstrating protective effects in in both ApoE-/- atherosclerotic and db/db diabetic models [191]. Here, APOE is linked to atherosclerosis.