UCP1 and Hyperglycemia: However, when these authors incubated these cells with thenoyltrifluoroacetone (TTFA, an inhibitor of complex II), carbonyl cyanide m-chlorophenylhydrazone (CCCP, an uncoupler of oxidative phosphorylation), uncoupling protein-1 (UCP1, a specific protein uncoupler of oxidative phosphorylation), or manganese superoxide dismutase (Mn-SOD), they found that AGEs formation induced by hyperglycemia was prevented [23].