Shabanali et al. [125] transduced a lentiviral vector bearing the LAMP2b-DARPin G3 chimeric gene into HEK293T cells and successfully delivered siRNA against the TPD52 gene into HER2-positive breast cancer cells through targeted EVs bearing the Lamp2B-DARPin chimeric protein, modulating TPD52 gene expression. The gene discussed is TPD52; the disease is breast cancer.